The table below shows Wolverhampton Wanderers's overall record against each of their Premier League opponents.
| Opposition | P | W | D | L | F | A |
|---|---|---|---|---|---|---|
| AFC Bournemouth | 12 | 5 | 2 | 5 | 11 | 12 |
| Arsenal | 24 | 3 | 4 | 17 | 17 | 47 |
| Aston Villa | 22 | 8 | 6 | 8 | 25 | 28 |
| Birmingham City | 6 | 1 | 3 | 2 | 6 | 7 |
| Blackburn Rovers | 8 | 1 | 2 | 5 | 9 | 20 |
| Blackpool | 2 | 1 | 0 | 1 | 5 | 2 |
| Bolton Wanderers | 8 | 1 | 2 | 5 | 9 | 13 |
| Brentford | 10 | 3 | 3 | 4 | 15 | 17 |
| Brighton and Hove Albion | 16 | 2 | 7 | 7 | 14 | 31 |
| Burnley | 14 | 4 | 5 | 5 | 13 | 17 |
| Cardiff City | 2 | 1 | 0 | 1 | 3 | 2 |
| Charlton Athletic | 2 | 0 | 0 | 2 | 0 | 6 |
| Chelsea | 24 | 6 | 4 | 14 | 24 | 56 |
| Crystal Palace | 16 | 4 | 2 | 10 | 16 | 25 |
| Everton | 24 | 8 | 8 | 8 | 30 | 31 |
| Fulham | 20 | 8 | 7 | 5 | 23 | 23 |
| Huddersfield Town | 2 | 0 | 0 | 2 | 0 | 3 |
| Hull City | 2 | 0 | 2 | 0 | 3 | 3 |
| Ipswich Town | 2 | 1 | 0 | 1 | 3 | 3 |
| Leeds United | 10 | 3 | 1 | 6 | 13 | 21 |
| Leicester City | 14 | 5 | 4 | 5 | 17 | 17 |
| Liverpool | 24 | 3 | 2 | 19 | 14 | 42 |
| Luton Town | 2 | 1 | 1 | 0 | 3 | 2 |
| Manchester City | 24 | 5 | 2 | 17 | 23 | 57 |
| Manchester United | 24 | 6 | 4 | 14 | 19 | 37 |
| Middlesbrough | 2 | 1 | 0 | 1 | 2 | 2 |
| Newcastle United | 22 | 2 | 12 | 8 | 21 | 33 |
| Norwich City | 6 | 2 | 3 | 1 | 9 | 6 |
| Nottingham Forest | 8 | 1 | 5 | 2 | 6 | 9 |
| Portsmouth | 4 | 0 | 2 | 2 | 1 | 4 |
| Queens Park Rangers | 2 | 1 | 0 | 1 | 2 | 4 |
| Sheffield United | 6 | 3 | 1 | 2 | 6 | 4 |
| Southampton | 14 | 9 | 2 | 3 | 22 | 17 |
| Stoke City | 6 | 1 | 2 | 3 | 6 | 10 |
| Sunderland | 8 | 4 | 2 | 2 | 13 | 13 |
| Swansea City | 2 | 0 | 2 | 0 | 6 | 6 |
| Tottenham Hotspur | 24 | 9 | 5 | 10 | 33 | 37 |
| Watford | 6 | 4 | 0 | 2 | 11 | 5 |
| West Bromwich Albion | 6 | 1 | 2 | 3 | 8 | 13 |
| West Ham United | 20 | 9 | 1 | 10 | 22 | 27 |
| Wigan Athletic | 6 | 2 | 0 | 4 | 7 | 10 |