The table below shows Leeds United's overall record against each of their Premier League opponents.
| Opposition | P | W | D | L | F | A |
|---|---|---|---|---|---|---|
| AFC Bournemouth | 4 | 1 | 2 | 1 | 9 | 11 |
| Arsenal | 32 | 8 | 5 | 19 | 30 | 67 |
| Aston Villa | 32 | 8 | 12 | 12 | 28 | 33 |
| Barnsley | 2 | 2 | 0 | 0 | 5 | 3 |
| Birmingham City | 4 | 1 | 0 | 3 | 4 | 8 |
| Blackburn Rovers | 20 | 9 | 5 | 6 | 33 | 25 |
| Bolton Wanderers | 10 | 5 | 1 | 4 | 16 | 13 |
| Bradford City | 4 | 3 | 1 | 0 | 11 | 4 |
| Brentford | 6 | 1 | 4 | 1 | 7 | 9 |
| Brighton and Hove Albion | 8 | 1 | 3 | 4 | 4 | 10 |
| Burnley | 6 | 4 | 1 | 1 | 12 | 5 |
| Charlton Athletic | 10 | 6 | 3 | 1 | 23 | 10 |
| Chelsea | 32 | 10 | 10 | 12 | 39 | 35 |
| Coventry City | 18 | 8 | 7 | 3 | 32 | 21 |
| Crystal Palace | 14 | 6 | 3 | 5 | 17 | 17 |
| Derby County | 12 | 6 | 6 | 0 | 24 | 10 |
| Everton | 32 | 9 | 13 | 10 | 31 | 39 |
| Fulham | 12 | 5 | 1 | 6 | 15 | 16 |
| Ipswich Town | 10 | 5 | 2 | 3 | 14 | 10 |
| Leicester City | 22 | 9 | 3 | 10 | 30 | 32 |
| Liverpool | 32 | 7 | 7 | 18 | 33 | 72 |
| Manchester City | 22 | 7 | 5 | 10 | 26 | 36 |
| Manchester United | 32 | 5 | 10 | 17 | 27 | 56 |
| Middlesbrough | 18 | 6 | 8 | 4 | 23 | 21 |
| Newcastle United | 30 | 7 | 10 | 13 | 41 | 46 |
| Norwich City | 8 | 3 | 1 | 4 | 10 | 15 |
| Nottingham Forest | 14 | 5 | 3 | 6 | 18 | 22 |
| Oldham Athletic | 4 | 2 | 2 | 0 | 6 | 3 |
| Portsmouth | 2 | 0 | 0 | 2 | 2 | 8 |
| Queens Park Rangers | 8 | 3 | 2 | 3 | 16 | 11 |
| Sheffield United | 6 | 4 | 1 | 1 | 11 | 7 |
| Sheffield Wednesday | 16 | 7 | 5 | 4 | 29 | 23 |
| Southampton | 30 | 15 | 9 | 6 | 39 | 19 |
| Sunderland | 12 | 8 | 1 | 3 | 17 | 8 |
| Swindon Town | 2 | 2 | 0 | 0 | 8 | 0 |
| Tottenham Hotspur | 32 | 11 | 7 | 14 | 44 | 52 |
| Watford | 4 | 4 | 0 | 0 | 9 | 2 |
| West Bromwich Albion | 4 | 3 | 1 | 0 | 11 | 2 |
| West Ham United | 28 | 16 | 5 | 7 | 44 | 29 |
| Wimbledon | 16 | 6 | 5 | 5 | 23 | 17 |
| Wolverhampton Wanderers | 10 | 6 | 1 | 3 | 21 | 13 |