The table below shows Everton's overall record against each of their Premier League opponents.
| Opposition | P | W | D | L | F | A |
|---|---|---|---|---|---|---|
| AFC Bournemouth | 18 | 7 | 2 | 9 | 29 | 30 |
| Arsenal | 68 | 12 | 16 | 40 | 58 | 128 |
| Aston Villa | 62 | 14 | 21 | 27 | 70 | 89 |
| Barnsley | 2 | 1 | 1 | 0 | 6 | 4 |
| Birmingham City | 14 | 5 | 8 | 1 | 16 | 12 |
| Blackburn Rovers | 36 | 15 | 8 | 13 | 39 | 37 |
| Blackpool | 2 | 1 | 1 | 0 | 7 | 5 |
| Bolton Wanderers | 26 | 13 | 6 | 7 | 39 | 30 |
| Bradford City | 4 | 3 | 1 | 0 | 7 | 1 |
| Brentford | 10 | 3 | 4 | 3 | 13 | 13 |
| Brighton and Hove Albion | 18 | 8 | 5 | 5 | 29 | 22 |
| Burnley | 20 | 11 | 2 | 7 | 31 | 17 |
| Cardiff City | 4 | 3 | 1 | 0 | 6 | 1 |
| Charlton Athletic | 16 | 7 | 3 | 6 | 21 | 18 |
| Chelsea | 68 | 15 | 22 | 31 | 68 | 105 |
| Coventry City | 18 | 3 | 9 | 6 | 15 | 19 |
| Crystal Palace | 34 | 17 | 11 | 6 | 56 | 35 |
| Derby County | 14 | 7 | 2 | 5 | 17 | 15 |
| Fulham | 38 | 21 | 5 | 12 | 59 | 37 |
| Huddersfield Town | 4 | 3 | 1 | 0 | 6 | 1 |
| Hull City | 10 | 5 | 3 | 2 | 22 | 12 |
| Ipswich Town | 12 | 5 | 3 | 4 | 15 | 11 |
| Leeds United | 32 | 10 | 13 | 9 | 39 | 31 |
| Leicester City | 36 | 12 | 17 | 7 | 53 | 46 |
| Liverpool | 68 | 11 | 26 | 31 | 59 | 96 |
| Luton Town | 2 | 0 | 1 | 1 | 2 | 3 |
| Manchester City | 58 | 18 | 12 | 28 | 63 | 94 |
| Manchester United | 68 | 11 | 14 | 43 | 63 | 125 |
| Middlesbrough | 30 | 14 | 9 | 7 | 45 | 28 |
| Newcastle United | 62 | 25 | 13 | 24 | 85 | 86 |
| Norwich City | 20 | 7 | 7 | 6 | 25 | 26 |
| Nottingham Forest | 18 | 11 | 2 | 5 | 28 | 13 |
| Oldham Athletic | 4 | 2 | 1 | 1 | 5 | 4 |
| Portsmouth | 14 | 9 | 1 | 4 | 16 | 11 |
| Queens Park Rangers | 14 | 5 | 3 | 6 | 23 | 26 |
| Reading | 6 | 3 | 1 | 2 | 8 | 5 |
| Sheffield United | 12 | 5 | 3 | 4 | 12 | 11 |
| Sheffield Wednesday | 16 | 3 | 5 | 8 | 20 | 30 |
| Southampton | 50 | 22 | 12 | 16 | 66 | 54 |
| Stoke City | 20 | 9 | 6 | 5 | 27 | 19 |
| Sunderland | 34 | 17 | 7 | 10 | 58 | 36 |
| Swansea City | 14 | 6 | 6 | 2 | 18 | 10 |
| Swindon Town | 2 | 1 | 1 | 0 | 7 | 3 |
| Tottenham Hotspur | 68 | 10 | 25 | 33 | 65 | 112 |
| Watford | 16 | 8 | 4 | 4 | 29 | 23 |
| West Bromwich Albion | 26 | 14 | 6 | 6 | 35 | 26 |
| West Ham United | 60 | 29 | 16 | 15 | 94 | 58 |
| Wigan Athletic | 16 | 8 | 6 | 2 | 25 | 14 |
| Wimbledon | 16 | 6 | 6 | 4 | 24 | 21 |
| Wolverhampton Wanderers | 24 | 8 | 8 | 8 | 31 | 30 |