The table below shows Arsenal's overall record against each of their Premier League opponents.
| Opposition | P | W | D | L | F | A |
|---|---|---|---|---|---|---|
| AFC Bournemouth | 18 | 12 | 2 | 4 | 41 | 19 |
| Aston Villa | 62 | 33 | 15 | 14 | 107 | 59 |
| Barnsley | 2 | 2 | 0 | 0 | 7 | 0 |
| Birmingham City | 14 | 9 | 4 | 1 | 28 | 8 |
| Blackburn Rovers | 36 | 19 | 8 | 9 | 70 | 36 |
| Blackpool | 2 | 2 | 0 | 0 | 9 | 1 |
| Bolton Wanderers | 26 | 15 | 6 | 5 | 46 | 27 |
| Bradford City | 4 | 2 | 1 | 1 | 6 | 3 |
| Brentford | 10 | 6 | 3 | 1 | 16 | 8 |
| Brighton and Hove Albion | 18 | 8 | 5 | 5 | 25 | 18 |
| Burnley | 20 | 15 | 4 | 1 | 38 | 9 |
| Cardiff City | 4 | 4 | 0 | 0 | 10 | 3 |
| Charlton Athletic | 16 | 12 | 2 | 2 | 36 | 12 |
| Chelsea | 68 | 28 | 20 | 20 | 97 | 88 |
| Coventry City | 18 | 10 | 5 | 3 | 25 | 13 |
| Crystal Palace | 34 | 21 | 9 | 4 | 70 | 34 |
| Derby County | 14 | 10 | 3 | 1 | 27 | 11 |
| Everton | 68 | 40 | 16 | 12 | 128 | 58 |
| Fulham | 38 | 26 | 8 | 4 | 81 | 29 |
| Huddersfield Town | 4 | 4 | 0 | 0 | 9 | 1 |
| Hull City | 10 | 8 | 1 | 1 | 25 | 8 |
| Ipswich Town | 12 | 10 | 2 | 0 | 28 | 4 |
| Leeds United | 32 | 19 | 5 | 8 | 67 | 30 |
| Leicester City | 36 | 23 | 8 | 5 | 76 | 37 |
| Liverpool | 68 | 18 | 24 | 26 | 85 | 114 |
| Luton Town | 2 | 2 | 0 | 0 | 6 | 3 |
| Manchester City | 58 | 25 | 13 | 20 | 83 | 77 |
| Manchester United | 68 | 22 | 19 | 27 | 80 | 92 |
| Middlesbrough | 30 | 17 | 8 | 5 | 64 | 27 |
| Newcastle United | 62 | 38 | 11 | 13 | 100 | 47 |
| Norwich City | 20 | 11 | 7 | 2 | 45 | 19 |
| Nottingham Forest | 18 | 11 | 5 | 2 | 28 | 10 |
| Oldham Athletic | 4 | 2 | 2 | 0 | 4 | 1 |
| Portsmouth | 14 | 8 | 6 | 0 | 28 | 8 |
| Queens Park Rangers | 14 | 6 | 5 | 3 | 15 | 12 |
| Reading | 6 | 6 | 0 | 0 | 20 | 5 |
| Sheffield United | 12 | 6 | 4 | 2 | 26 | 7 |
| Sheffield Wednesday | 16 | 7 | 4 | 5 | 21 | 16 |
| Southampton | 50 | 27 | 15 | 8 | 94 | 52 |
| Stoke City | 20 | 12 | 3 | 5 | 37 | 17 |
| Sunderland | 34 | 20 | 11 | 3 | 61 | 21 |
| Swansea City | 14 | 7 | 1 | 6 | 24 | 19 |
| Swindon Town | 2 | 1 | 1 | 0 | 5 | 1 |
| Tottenham Hotspur | 68 | 29 | 24 | 15 | 116 | 84 |
| Watford | 16 | 13 | 1 | 2 | 36 | 14 |
| West Bromwich Albion | 26 | 18 | 4 | 4 | 54 | 25 |
| West Ham United | 60 | 39 | 11 | 10 | 117 | 47 |
| Wigan Athletic | 16 | 12 | 2 | 2 | 38 | 14 |
| Wimbledon | 16 | 7 | 4 | 5 | 30 | 16 |
| Wolverhampton Wanderers | 24 | 17 | 4 | 3 | 47 | 17 |