Manchester United v Southampton, 28 October 2000
| Score | 5-0 to Manchester United |
| Referee | Andy D' Urso |
| Competition | Premier League |
| Venue | Old Trafford |
| Attendance | 67,581 |
View Manchester United v Southampton head to head
Goals:
| Andrew Cole | 9 |
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| Teddy Sheringham | 45 |
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| Teddy Sheringham | 51 |
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| Teddy Sheringham | 55 |
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| Andrew Cole | 73 |
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Starting lineup:
Goalkeeper
Fabien Barthez
Defender
Wes Brown
Defender
Denis Irwin
Defender
Gary Neville
Defender
Phil Neville
Midfielder
David Beckham
Midfielder
Nicky Butt
Midfielder
Ryan Giggs
Midfielder
Paul Scholes
Forward
Andrew Cole
Forward
Teddy Sheringham
Substitutions:
| Ronnie Wallwork for Gary Neville | 59 |
| Dwight Yorke for Teddy Sheringham | 75 |
| Ole Gunnar Solskjær for Andrew Cole | 75 |
Goals:
Starting lineup:
Paul Jones
Goalkeeper
Jason Dodd
Defender/Right back
Wayne Bridge
Defender
Claus Lundekvam
Defender
Tahar El Khalej
Defender/Midfielder
Mark Draper
Midfielder
Hassan Kachloul
Midfielder
Matt Oakley
Midfielder
Jo Tessem
Midfielder
Kevin Davies
Forward
Marian Pahars
Forward
Substitutions:
| James Beattie for Jo Tessem | 66 |
| Chris Marsden for Matt Oakley | 72 |
| Francis Benali for Tahar El Khalej | 81 |