Southampton v Manchester City, 20 March 2022
| Score | 4-1 to Manchester City |
| Referee | Mike Dean |
| Competition | FA Cup Quarter-final |
| Venue | St Mary's Stadium, Southampton |
| Attendance | 29,702 |
View Southampton v Manchester City head to head
Kick-off: 3.00pm
1 Southampton
Manager: Ralph Hasenhüttl
Goals:
| Aymeric Laporte | own goal | 45 |
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Starting lineup:
Goalkeeper
Fraser Forster
Defender
Mohammed Salisu
Defender
Jack Stephens
Defender/Midfielder
Tino Livramento
Defender/Midfielder
Kyle Walker-Peters
Midfielder
Stuart Armstrong
Midfielder
James Ward-Prowse
Midfielder/Forward
Mohamed Elyounoussi
Midfielder/Forward
Oriol Romeu
Forward
Adam Armstrong
Forward
Shane Long
Substitutions:
| Che Adams for Adam Armstrong | 63 |
| Armando Broja for Shane Long | 63 |
| Moussa Djenepo for Stuart Armstrong | 83 |
| Ibrahima Diallo for Mohamed Elyounoussi | 88 |
| Will Smallbone for Oriol Romeu | 88 |
Cards:
On the bench:
Goalkeeper
Willy Caballero
Defender
Yann Valery
Defender/Midfielder
Romain Perraud
Midfielder
Ibrahima Diallo
Midfielder
Will Smallbone
Midfielder/Forward
Che Adams
Midfielder/Forward
Moussa Djenepo
Midfielder/Forward
Nathan Redmond
Forward
Armando Broja
4 Manchester City
Manager: Pep Guardiola
Goals:
| Raheem Sterling | 12 |
|
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| Kevin De Bruyne | penalty | 62 |
|
| Phil Foden | 75 |
|
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| Riyad Mahrez | 78 |
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Starting lineup:
Zack Steffen
Goalkeeper
Aymeric Laporte
Defender
Kyle Walker
Defender
João Cancelo
Defender/Midfielder
Rodri
Defender/Midfielder
John Stones
Defender/Midfielder
Ilkay Gündogan
Midfielder
Kevin De Bruyne
Midfielder/Forward
Jack Grealish
Midfielder/Forward
Raheem Sterling
Midfielder/Forward
Gabriel Jesus
Forward
Substitutions:
| Phil Foden for Jack Grealish | 64 |
| Riyad Mahrez for Gabriel Jesus | 64 |
| Olexsandr Zinchenko for João Cancelo | 82 |
| Fernandinho for Rodri | 83 |
| Nathan Aké for Aymeric Laporte | 83 |
Cards:
| Zack Steffen | 71 | Y |
On the bench:
Goalkeeper
Scott Carson
Defender
Nathan Aké
Defender/Midfielder
Fernandinho
Defender/Midfielder
Olexsandr Zinchenko
Midfielder/Forward
Bernardo Silva
Midfielder/Forward
Phil Foden
Midfielder/Forward
Riyad Mahrez