| Score | 2-1 to Brighton and Hove Albion |
| Referee | Anthony Taylor |
| Competition | FA Cup 5th round |
| Venue | St James' Park |
| Attendance | 51,566 |
View Newcastle United v Brighton and Hove Albion head to head
Manager: Eddie Howe
| Alexander Isak | penalty | 22 |
|
| Bruno Guimarães for Lewis Miley | 56 |
| Jacob Murphy for Harvey Barnes | 56 |
| Joe Willock for Joelinton | 56 |
| Matt Targett for Kieran Trippier | 69 |
| Callum Wilson for Alexander Isak | 86 |
| Joelinton | 36 | Y |
| Anthony Gordon | 83 | R |
Manager: Fabian Hürzeler
| Yankuba Minteh | 44 |
|
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| Danny Welbeck | 114 |
|
| Diego Gómez for Carlos Baleba | 69 |
| Brajan Gruda for Yankuba Minteh | 69 |
| Danny Welbeck for Georginio Rutter | 80 |
| Mats Wieffer for Pervis Estupiñán | 80 |
| Solly March for Kaoru Mitoma | 90+1 |
| Tariq Lamptey | 29 | Y |
| Adam Webster | 35 | Y |
| Carlos Baleba | 45+2 | Y |
| Tariq Lamptey | 90+1 | Y |
| Tariq Lamptey | 90+1 | R |
| Diego Gómez | 92 | Y |