Manchester United v Panathinaikos, 21 November 2000
| Score | 3-1 to Manchester United |
| Referee | Domenico Messina |
| Competition | UEFA Champions League Group A |
| Venue | Old Trafford |
| Attendance | 65,024 |
View Manchester United v Panathinaikos head to head
1 Panathinaikos
Goals:
| Teddy Sheringham | 48 |
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| Paul Scholes | 81 |
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| Paul Scholes | 90 |
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Goals:
| Giorgios Karagounis | 64 |
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Starting lineup:
Goalkeeper
Fabien Barthez
Defender
Wes Brown
Defender
Gary Neville
Defender
Phil Neville
Defender
Mikaël Silvestre
Midfielder
David Beckham
Midfielder
Nicky Butt
Midfielder
Roy Keane
Midfielder
Paul Scholes
Forward
Teddy Sheringham
Forward
Dwight Yorke
Starting lineup:
Goalkeeper
Antonis Nikopolidis
Defender
René Henriksen
Defender
Leonidas Vokolos
Midfielder
Angelos Basinas
Midfielder
Panagiotis Fyssas
Midfielder
Fernando-Edgar Galetto
Midfielder
Ioannis Goumas
Midfielder
Giorgios Karagounis
Forward
Nikos Liberopoulos
Forward
Igor Sipniewski
Forward
Krzysztof Warzycha
Substitutions:
Substitutions:
| Goran Vlaović for Giorgios Karagounis | 67 |
| Kostas Kiassos for Krzysztof Warzycha | 75 |
| Percy Olivares for Igor Sipniewski | 79 |