Lazio v Shakhtar Donetsk, 25 October 2000
| Score | 5-1 to Lazio |
| Competition | UEFA Champions League Group B |
| Venue | Stadio Olimpico, Rome |
| Attendance | 30,000 |
5 Lazio
Goals:
| Claudio Lopez | 48 |
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| Giuseppe Favalli | 54 |
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| Juan Sebastian Veron | 57 |
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| Claudio Lopez | 68 |
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| Claudio Lopez | 93 |
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Starting lineup:
Goalkeeper
Angelo Peruzzi
Defender
Giuseppe Favalli
Defender
Fernando Couto
Defender
Alessandro Nesta
Defender
Giuseppe Pancaro
Midfielder
Roberto Baronio
Midfielder
Attilio Lombardo
Midfielder
Pavel Nedvěd
Midfielder
Juan Sebastian Veron
Forward
Simone Inzaghi
Forward
Claudio Lopez
Substitutions:
| Hernan Crespo for Simone Inzaghi | 46 |
| Dejan Stanković for Roberto Baronio | 46 |
| Roberto Sensini for Attilio Lombardo | 71 |
Cards:
| Roberto Baronio | 38 | Y |
1 Shakhtar Donetsk
Goals:
| Andrey Vorobei | 41 |
|
Starting lineup:
Yuriy Virt
Goalkeeper
Dainius Gleveckas
Defender
Sergei Popov
Defender
Isaac Okoronkwo
Defender/Centre back
Marian Aliuță
Midfielder
Alexei Bakharev
Midfielder
Sergei Kovalov
Midfielder
Anatoliy Tymoshchuk
Midfielder
Gennadi Zubov
Midfielder
Sergei Atelkin
Forward
Andrey Vorobei
Forward
Substitutions:
| Oleksii Belik for Marian Aliuță | 71 |
| Alexander Shmarko for Sergei Popov | 75 |
| Mykhailo Starostyak for Sergei Kovalov | 84 |
Cards:
| Sergei Popov | 61 | Y |