Zenit St Petersburg v Real Betis, 17 February 2022
| Score | 3-2 to Real Betis |
| Referee | Benoît Bastien |
| Competition | UEFA Europa League Play-off 1st leg |
| Venue | Gazprom Arena, Saint Petersburg |
| Attendance | 28,936 |
Kick-off: 8.45pm local
2 Zenit St Petersburg
Manager: Sergei Semak
3 Real Betis
Manager: Manuel Pellegrini