Vitoria Guimaraes v Real Betis, 13 March 2025
| Score | 4-0 to Real Betis |
| Referee | Serdar Gözübüyük |
| Competition | UEFA Conference League Round of 16 2nd leg |
| Venue | Estadio D. Afonso Henriques, Guimaraes |
| Attendance | 28,994 |
Kick-off: 8.00pm local
.
Real Betis won 6-2 on aggregate
0 Vitoria Guimaraes
Manager: Luís Freire
4 Real Betis
Manager: Manuel Pellegrini