Sporting Clube Portugal v Ajax, 15 September 2021
| Score | 5-1 to Ajax |
| Referee | José María Sánchez |
| Competition | UEFA Champions League Group C |
| Venue | Estádio José Alvalade, Lisbon |
| Attendance | 20,382 |
Kick-off: 8.00pm local
1 Sporting Clube Portugal
Manager: Rúben Amorim
5 Ajax
Manager: Erik Ten Hag