Spartak Moscow v Napoli, 24 November 2021
| Score | 2-1 to Spartak Moscow |
| Referee | Clément Turpin |
| Competition | UEFA Europa League Group C |
| Venue | Otkrytie Arena, Moscow |
| Attendance | 10,852 |
Kick-off: 6.30pm local
2 Spartak Moscow
Manager: Rui Vitória
1 Napoli
Manager: Luciano Spalletti