Sparta Praha v Olympique Lyonnais, 21 October 2021
| Score | 4-3 to Olympique Lyonnais |
| Referee | Matej Jug |
| Competition | UEFA Europa League Group A |
| Venue | Stadion Letná, Prague |
| Attendance | 12,427 |
Kick-off: 9.00pm local
3 Sparta Praha
Manager: Pavel Vrba
4 Olympique Lyonnais
Manager: Peter Bosz