| Score | 3-1 to Brighton and Hove Albion |
| Referee | Rob Jones |
| Competition | Premier League |
| Venue | St Mary's Stadium, Southampton |
| Attendance | 31,010 |
View Southampton v Brighton and Hove Albion head to head
Manager: Nathan Jones
| James Ward-Prowse | 73 |
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| Joe Aribo for Moussa Djenepo | 46 |
| Stuart Armstrong for Ibrahima Diallo | 46 |
| Ainsley Maitland-Niles for Romain Perraud | 54 |
| Sékou Mara for Mohamed Elyounoussi | 78 |
| Adam Armstrong for Sam Edozie | 84 |
| Joe Aribo | 60 | Y |
Manager: Roberto De Zerbi
| Adam Lallana | 14 |
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| Romain Perraud | own goal | 35 |
|
| Solly March | 56 |
|
| Jeremy Sarmiento for Adam Lallana | 67 |
| Evan Ferguson for Leandro Trossard | 83 |
| Tariq Lamptey for Solly March | 83 |
| Billy Gilmour for Pascal Gross | 90 |
| Robert Sánchez | 73 | Y |
| Moisés Caicedo | 85 | Y |