Shakhtar Donetsk v FC Sheriff Tiraspol, 07 December 2021
| Score | 1-1 |
| Referee | Donatas Rumšas |
| Competition | UEFA Champions League Group D |
| Venue | NSC Olimpiyskiy Stadium, Kyiv |
| Attendance | 6,841 |
Kick-off: 10.00pm local
1 Shakhtar Donetsk
Manager: Roberto De Zerbi
1 FC Sheriff Tiraspol
Manager: Yuriy Vernydub