Shakhtar Donetsk v AS Roma, 18 March 2021
| Score | 2-1 to AS Roma |
| Referee | Antonio Mateu Lahoz |
| Competition | UEFA Europa League Round of 16 2nd leg |
| Venue | NSC Olimpiyskiy Stadium, Kyiv |
Kick-off: 7.55pm local
AS Roma won 5-1 on aggregate
Played in Kiev, rather than Donbass Arena in Donetsk, due to the war conditions in Eastern Ukraine.
Played behind closed doors due to COVID-19 restrictions.
1 Shakhtar Donetsk
Manager: Luís Castro
2 AS Roma
Manager: Paulo Fonseca