Sevilla v VfL Wolfsburg, 23 November 2021
| Score | 2-0 to Sevilla |
| Referee | Cüneyt Çakir |
| Competition | UEFA Champions League Group G |
| Venue | Estadio Ramón Sánchez Pizjuán, Sevilla |
| Attendance | 28,663 |
Kick-off: 9.00pm local
2 Sevilla
Manager: Julen Lopetegui
0 VfL Wolfsburg
Manager: Florian Kohfeldt