Sevilla v Lille OSC, 02 November 2021
| Score | 2-1 to Lille OSC |
| Referee | István Kovács |
| Competition | UEFA Champions League Group G |
| Venue | Estadio Ramón Sánchez Pizjuán, Sevilla |
| Attendance | 29,369 |
Kick-off: 9.00pm local
1 Sevilla
Manager: Julen Lopetegui
2 Lille OSC
Manager: Jocelyn Gourvennec