Sevilla v Borussia Dortmund, 17 February 2021
| Score | 3-2 to Borussia Dortmund |
| Referee | Danny Makkelie |
| Competition | UEFA Champions League Round of 16 1st leg |
| Venue | Estadio Ramón Sánchez Pizjuán, Sevilla |
Kick-off: 9.00pm local
Played behind closed doors due to COVID-19 restrictions.
2 Sevilla
Manager: Julen Lopetegui
3 Borussia Dortmund
Manager: Edin Terzić