Kick-off: 3.30pm local
Played at Skopje, rather than at Renovo's Ecolog Arena in Tetovo.
Due to COVID-19 restrictions, the UEFA Executive Committee decided that all ties played in the Preliminary round, three Qualifying rounds and Play-off round in this season's UEFA Europa League competition should be single-leg matches, hosted by one of the teams decided by draw and played behind closed doors.