Real Madrid v Shakhtar Donetsk, 03 November 2021
| Score | 2-1 to Real Madrid |
| Referee | Benoît Bastien |
| Competition | UEFA Champions League Group D |
| Venue | Santiago Bernabeu, Madrid |
| Attendance | 38,105 |
Kick-off: 6.45pm local
2 Real Madrid
Manager: Carlo Ancelotti
1 Shakhtar Donetsk
Manager: Roberto De Zerbi