Real Madrid v FC Sheriff Tiraspol, 28 September 2021
| Score | 2-1 to FC Sheriff Tiraspol |
| Referee | Lawrence Visser |
| Competition | UEFA Champions League Group D |
| Venue | Santiago Bernabeu, Madrid |
| Attendance | 24,522 |
Kick-off: 9.00pm local
1 Real Madrid
Manager: Carlo Ancelotti
2 FC Sheriff Tiraspol
Manager: Yuriy Vernydub