Real Betis v Zenit St Petersburg, 24 February 2022
| Score | 0-0 |
| Referee | Halil Umut Meler |
| Competition | UEFA Europa League Play-off 2nd leg |
| Venue | Estadio Benito Villamarín, Sevilla |
| Attendance | 44,236 |
Kick-off: 9.00pm local
Real Betis won 3-2 on aggregate
0 Real Betis
Manager: Manuel Pellegrini
0 Zenit St Petersburg
Manager: Sergei Semak