Real Betis v F91 Dudelange, 04 October 2018
| Score | 3-0 to Real Betis |
| Referee | Andrew Dallas |
| Competition | UEFA Europa League Group F |
| Venue | Estadio Benito Villamarín, Sevilla |
| Attendance | 40,133 |
Kick-off: 6.55pm local (5.55pm BST)
3 Real Betis
Manager: Quique Setién
0 F91 Dudelange
Manager: Dino Toppmöller