Real Betis v Eintracht Frankfurt, 09 March 2022
| Score | 2-1 to Eintracht Frankfurt |
| Referee | Marco Guida |
| Competition | UEFA Europa League Round of 16 1st leg |
| Venue | Estadio Benito Villamarín, Sevilla |
| Attendance | 36,574 |
Kick-off: 6.45pm local
1 Real Betis
Manager: Manuel Pellegrini
2 Eintracht Frankfurt
Manager: Oliver Glasner