Real Betis v Celtic, 16 September 2021
| Score | 4-3 to Real Betis |
| Referee | Fran Jović |
| Competition | UEFA Europa League Group G |
| Venue | Estadio Benito Villamarín, Sevilla |
| Attendance | 30,893 |
Kick-off: 6.45pm local (5.45pm BST)
4 Real Betis
Manager: Manuel Pellegrini
3 Celtic
Manager: Ange Postecoglou