Real Betis v Bayer Leverkusen, 21 October 2021
| Score | 1-1 |
| Referee | Bartosz Frankowski |
| Competition | UEFA Europa League Group G |
| Venue | Estadio Benito Villamarín, Sevilla |
| Attendance | 39,230 |
Kick-off: 6.45pm local
1 Real Betis
Manager: Manuel Pellegrini
1 Bayer Leverkusen
Manager: Gerardo Seoane