RB Leipzig v Shakhtar Donetsk, 06 September 2022
| Score | 4-1 to Shakhtar Donetsk |
| Referee | João Pinheiro |
| Competition | UEFA Champions League Group F |
| Venue | Red Bull Arena, Leipzig |
| Attendance | 41,591 |
Kick-off: 9.00pm local
1 RB Leipzig
Manager: Domenico Tedesco
4 Shakhtar Donetsk
Manager: Igor Jovicevic