PSV Eindhoven v AS Monaco, 21 October 2021
| Score | 2-1 to AS Monaco |
| Referee | Davide Massa |
| Competition | UEFA Europa League Group B |
| Venue | Philips Stadium, Eindhoven |
| Attendance | 33,000 |
Kick-off: 9.00pm local
1 PSV Eindhoven
Manager: Roger Schmidt
2 AS Monaco
Manager: Niko Kovač