Preston North End v Manchester United, 24 September 1921
| Score | 3-2 to Preston North End |
| Competition | League Division One |
| Attendance | 25,000 |
View Preston North End v Manchester United head to head
Goals:
| Arthur Lochhead |
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| Edward Partridge |
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Starting lineup:
John Mew
Goalkeeper
Charles Radford
Full back
John Silcock
Full back
Clarence Hilditch
Wing half
John Scott
Wing half
John Grimwood
Half Back
James Robinson
Outside left
William Harrison
Outside right
Edward Partridge
Forward
Joe Spence
Forward
Arthur Lochhead
Inside left