Olympique Lyonnais v Sparta Praha, 04 November 2021
| Score | 3-0 to Olympique Lyonnais |
| Referee | Maurizio Mariani |
| Competition | UEFA Europa League Group A |
| Venue | Groupama Stadium, Lyon |
| Attendance | 33,934 |
Kick-off: 6.45pm local
3 Olympique Lyonnais
Manager: Peter Bosz
0 Sparta Praha
Manager: Pavel Vrba