Olympique Lyonnais v FC Porto, 17 March 2022
| Score | 1-1 |
| Referee | Ovidiu Haţegan |
| Competition | UEFA Europa League Round of 16 2nd leg |
| Venue | Groupama Stadium, Lyon |
| Attendance | 54,551 |
Kick-off: 9.00pm local
Olympique Lyonnais won 2-1 on aggregate
1 Olympique Lyonnais
Manager: Peter Bosz
1 FC Porto
Manager: Sérgio Conceição