Olympiakos v Royal Antwerp, 16 September 2021
| Score | 2-1 to Olympiakos |
| Referee | Tamás Bognár |
| Competition | UEFA Europa League Group D |
| Venue | Karaiskakis Stadium, Piraeus |
| Attendance | 15,615 |
Kick-off: 10.00pm local
2 Olympiakos
Manager: Pedro Martins
1 Royal Antwerp
Manager: Brian Priske