Olympiakos v Fenerbahçe, 25 November 2021
| Score | 1-0 to Olympiakos |
| Referee | Antonio Mateu Lahoz |
| Competition | UEFA Europa League Group D |
| Venue | Karaiskakis Stadium, Piraeus |
Kick-off: 10.00pm
1 Olympiakos
Manager: Pedro Martins
0 Fenerbahçe
Manager: Vítor Pereira