Olympiakos v Eintracht Frankfurt, 04 November 2021
| Score | 2-1 to Eintracht Frankfurt |
| Referee | Aleksei Kulbakov |
| Competition | UEFA Europa League Group D |
| Venue | Karaiskakis Stadium, Piraeus |
| Attendance | 23,050 |
Kick-off: 7.45pm local
1 Olympiakos
Manager: Pedro Martins
2 Eintracht Frankfurt
Manager: Oliver Glasner