Olympiakos v Astana, 20 October 2016
| Score | 4-1 to Olympiakos |
| Referee | Tobias Stieler |
| Competition | UEFA Europa League Group B |
| Venue | Georgios Karaiskakis Stadium, Athens |
| Attendance | 21,480 |
Kick-off: 10.05pm local
4 Olympiakos
Manager: Paulo Bento
1 Astana
Manager: Stanimir Stoilov