Napoli v Spartak Moscow, 30 September 2021
| Score | 3-2 to Spartak Moscow |
| Referee | Ivan Kružliak |
| Competition | UEFA Europa League Group C |
| Venue | Stadio Diego Armando Maradona, Naples |
| Attendance | 13,373 |
Kick-off: 6.45pm local
2 Napoli
Manager: Luciano Spalletti
3 Spartak Moscow
Manager: Rui Vitória