Napoli v Granada, 25 February 2021
| Score | 2-1 to Napoli |
| Referee | Daniel Siebert |
| Competition | UEFA Europa League Round of 32 2nd leg |
| Venue | Stadio Diego Armando Maradona, Naples |
Kick-off: 6.55pm local
Granada won 3-2 on aggregate.
Played behind closed doors due to COVID-19 restrictions.
2 Napoli
Manager: Gennaro Gattuso
1 Granada
Manager: Diego Martinez