Napoli v Benfica, 28 September 2016
| Score | 4-2 to Napoli |
| Referee | Felix Brych |
| Competition | UEFA Champions League Group B |
| Venue | San Paolo, Naples |
| Attendance | 41,281 |
Kick-off: 8.45pm local (7.45pm BST)
4 Napoli
Manager: Maurizio Sarri
2 Benfica
Manager: Rui Vitoria