Napoli v Barcelona, 24 February 2022
| Score | 4-2 to Barcelona |
| Referee | Sergei Karasev |
| Competition | UEFA Europa League Play-off 2nd leg |
| Venue | Stadio Diego Armando Maradona, Naples |
| Attendance | 37,858 |
Kick-off: 9.00pm local
Barcelona won 5-3 on aggregate
2 Napoli
Manager: Luciano Spalletti
4 Barcelona
Manager: Xavi Hernández