Napoli v Ajax, 12 October 2022
| Score | 4-2 to Napoli |
| Referee | Felix Zwayer |
| Competition | UEFA Champions League Group A |
| Venue | Stadio Diego Armando Maradona, Naples |
| Attendance | 52,229 |
Kick-off: 6.45pm local
4 Napoli
Manager: Luciano Spalletti
2 Ajax
Manager: Alfred Schreuder