Milton Keynes Dons v Southampton, 11 November 2020
| Score | 2-1 to Southampton |
| Competition | Football League Trophy Group C – South |
| Venue | Stadium MK |
View Milton Keynes Dons v Southampton head to head
Kick-off: 7.00pm
Played behind closed doors due to COVID-19 restrictions.
In line with Premier League and League Championship clubs being allowed to enter the competition, Southampton fielded their Category One Academy team as part of the Elite Player Performance Plan (EPPP) youth development scheme initiated by the Premier League.