Manchester United v Manchester City, 29 October 1921
| Score | 3-1 to Manchester United |
| Competition | League Division One |
| Venue | Old Trafford |
| Attendance | 56,000 |
View Manchester United v Manchester City head to head
Goals:
| Joe Spence |
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| Joe Spence |
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| Joe Spence |
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Starting lineup:
Goalkeeper
John Mew
Full back
Charles Radford
Full back
John Silcock
Wing half
Thomas Forster
Wing half
Clarence Hilditch
Wing half
John Scott
Outside right
William Harrison
Forward
Edward Partridge
Forward
Joe Spence
Inside left
Arthur Lochhead
Inside left
George Sapsford