Manchester United v Atlético Madrid, 15 March 2022
| Score | 1-0 to Atlético Madrid |
| Referee | Slavko Vinčić |
| Competition | UEFA Champions League Round of 16 2nd leg |
| Venue | Old Trafford |
| Attendance | 73,008 |
View Manchester United v Atlético Madrid head to head
Kick-off: 8.00pm GMT
Atlético Madrid won 2-1 on aggregate
0 Manchester United
Manager: Ralph Rangnick
Starting lineup:
Goalkeeper
David De Gea
Defender
Alex Telles
Defender
Harry Maguire
(captain)
Defender
Raphaël Varane
Defender/Midfielder
Diogo Dalot
Defender/Midfielder/Forward
Scott McTominay
Midfielder
Bruno Fernandes
Midfielder
Fred
Midfielder/Forward
Anthony Elanga
Midfielder/Forward
Jadon Sancho
Forward
Cristiano Ronaldo
Substitutions:
| Nemanja Matić for Scott McTominay | 68 |
| Paul Pogba for Bruno Fernandes | 68 |
| Marcus Rashford for Anthony Elanga | 68 |
| Edinson Cavani for Fred | 75 |
| Juan Mata for Harry Maguire | 84 |
Cards:
| Nemanja Matić | 81 | Y |
| Diogo Dalot | 87 | Y |
On the bench:
Goalkeeper
Tom Heaton
Goalkeeper
Dean Henderson
Defender
Eric Bailly
Defender
Victor Lindelöf
Defender/Midfielder
Phil Jones
Defender/Midfielder
Nemanja Matić
Defender/Midfielder
Aaron Wan-Bissaka
Midfielder
Juan Mata
Midfielder
Paul Pogba
Midfielder/Forward
Jesse Lingard
Midfielder/Forward
Marcus Rashford
Forward
Edinson Cavani
1 Atlético Madrid
Manager: Diego Simeone