Manchester United v AS Roma, 29 April 2021
| Score | 6-2 to Manchester United |
| Referee | Carlos Del Cerro Grande |
| Competition | UEFA Europa League Semi-final 1st leg |
| Venue | Old Trafford |
View Manchester United v AS Roma head to head
Kick-off: 8.00pm BST
Played behind closed doors due to COVID-19 restrictions.
6 Manchester United
Manager: Ole Gunnar Solskjær
Goals:
| Bruno Fernandes | 9 |
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| Edinson Cavani | 48 |
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| Edinson Cavani | 64 |
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| Bruno Fernandes | penalty | 71 |
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| Paul Pogba | 75 |
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| Mason Greenwood | 86 |
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Starting lineup:
Goalkeeper
David De Gea
Defender
Victor Lindelöf
Defender
Harry Maguire
(captain)
Defender
Luke Shaw
Defender/Midfielder
Aaron Wan-Bissaka
Defender/Midfielder/Forward
Scott McTominay
Midfielder
Bruno Fernandes
Midfielder
Fred
Midfielder
Paul Pogba
Midfielder/Forward
Marcus Rashford
Forward
Edinson Cavani
Substitutions:
| Mason Greenwood for Marcus Rashford | 76 |
| Nemanja Matić for Fred | 83 |
| Juan Mata for Bruno Fernandes | 89 |
Cards:
| Paul Pogba | 51 | Y |
On the bench:
Goalkeeper
Lee Grant
Goalkeeper
Dean Henderson
Defender
Alex Telles
Defender
Eric Bailly
Defender
Axel Tuanzebe
Defender
Brandon Williams
Defender/Midfielder
Nemanja Matić
Midfielder
Juan Mata
Midfielder
Donny van de Beek
Midfielder/Forward
Daniel James
Forward
Amad Diallo
Forward
Mason Greenwood
2 AS Roma
Manager: Paulo Fonseca