Lille OSC v VfL Wolfsburg, 14 September 2021
| Score | 0-0 |
| Referee | Danny Makkelie |
| Competition | UEFA Champions League Group G |
| Venue | Stade Pierre-Mauroy, Villeneuve D'Ascq |
| Attendance | 34,314 |
Kick-off: 9.00pm local
0 Lille OSC
Manager: Jocelyn Gourvennec
0 VfL Wolfsburg
Manager: Mark van Bommel