Lille OSC v Red Bull Salzburg, 23 November 2021
| Score | 1-0 to Lille OSC |
| Referee | Anthony Taylor |
| Competition | UEFA Champions League Group G |
| Venue | Stade Pierre-Mauroy, Villeneuve D'Ascq |
| Attendance | 33,573 |
Kick-off: 9.00pm local
1 Lille OSC
Manager: Jocelyn Gourvennec
0 Red Bull Salzburg
Manager: Matthias Jaissle