Leyton Orient v Tranmere Rovers, 04 December 2021
| Score | 4-0 to Leyton Orient |
| Competition | FA Cup 2nd round |
| Venue | The Breyer Group Stadium |
| Attendance | 3,248 |
View Leyton Orient v Tranmere Rovers head to head
Kick-off: 3.00pm
| Score | 4-0 to Leyton Orient |
| Competition | FA Cup 2nd round |
| Venue | The Breyer Group Stadium |
| Attendance | 3,248 |
View Leyton Orient v Tranmere Rovers head to head