Leyton Orient v Milton Keynes Dons, 30 November 2021
| Score | 0-0 :: penalties 5-4 to Milton Keynes Dons |
| Competition | Football League Trophy 2nd round - southern section |
| Venue | The Breyer Group Stadium |
View Leyton Orient v Milton Keynes Dons head to head
Kick-off: 7.00pm
Milton Keynes Dons won 5-4 on penalties
Extra time not played